TRPM8 anticorps (AA 980-1104)
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- Antigène Voir toutes TRPM8 Anticorps
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
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Épitope
- AA 980-1104
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TRPM8 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- GYTVGTVQEN NDQVWKFQRY FLVQEYCSRL NIPFPFIVFA YFYMVVKKCF KCCCKEKNME SSVCCFKNED NETLAWEGVM KENYLVKINT KANDTSEEMR HRFRQLDTKL NDLKGLLKEI ANKIK
- Réactivité croisée
- Humain
- Attributs du produit
- Polyclonal Antibodies
- Immunogène
- Recombinant fusion protein containing a sequence corresponding to amino acids 980-1104 of human TRPM8 (NP_076985.4).
- Isotype
- IgG
- Top Product
- Discover our top product TRPM8 Anticorps primaire
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- Indications d'application
- WB,1:500 - 1:2000
- Commentaires
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- Autre désignation
- TRPM8 (TRPM8 Produits)
- Synonymes
- anticorps TRPM8, anticorps trpp8, anticorps ltrpc6, anticorps trpm8b, anticorps LTRPC6, anticorps TRPP8, anticorps CMR1, anticorps LTrpC-6, anticorps Trp-p8, anticorps transient receptor potential cation channel subfamily M member 8, anticorps transient receptor potential cation channel subfamily M member 8b L homeolog, anticorps transient receptor potential cation channel, subfamily M, member 8, anticorps TRPM8, anticorps trpm8b.L, anticorps Trpm8
- Sujet
- Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.,TRPM8,LTRPC6,TRPP8,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,TRPM8
- Poids moléculaire
- 5 kDa/18 kDa/79 kDa/127 kDa
- ID gène
- 79054
- UniProt
- Q7Z2W7
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