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Insulin anticorps

INS Reactivité: Humain, Porc, Souris, Boeuf (Vache), Rat IF, FACS, IHC (f) Hôte: Souris Monoclonal IRDN-794 unconjugated
N° du produit ABIN6157480
  • Antigène Voir toutes Insulin (INS) Anticorps
    Insulin (INS)
    Reactivité
    • 189
    • 105
    • 90
    • 75
    • 69
    • 40
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Porc, Souris, Boeuf (Vache), Rat
    Hôte
    • 136
    • 86
    • 13
    • 2
    • 1
    • 1
    Souris
    Clonalité
    • 143
    • 98
    Monoclonal
    Conjugué
    • 120
    • 20
    • 15
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Insulin est non-conjugé
    Application
    • 83
    • 74
    • 66
    • 66
    • 66
    • 55
    • 46
    • 39
    • 26
    • 24
    • 21
    • 17
    • 16
    • 11
    • 9
    • 9
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Fonction
    Mouse Monoclonal anti-Insulin (IRDN/794), Purified, BSA-free
    Attributs du produit
    This antibody recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Purification
    Purified
    Immunogène
    Recombinant INS protein
    Clone
    IRDN-794
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product INS Anticorps primaire
  • Indications d'application
    Immunohistology formalin-fixed 0.1-0.2 μg/mL
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 1-2 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Commentaires

    MIA PaCa-2 cells or Pancreas

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (no BSA, no azide)
    Agent conservateur
    Azide free
  • Antigène
    Insulin (INS)
    Autre désignation
    Insulin (INS Produits)
    Synonymes
    anticorps IDDM2, anticorps ILPR, anticorps IRDN, anticorps MODY10, anticorps ins1, anticorps xins, anticorps ins1-a, anticorps Insulin, anticorps AA986540, anticorps Ins-2, anticorps InsII, anticorps Mody, anticorps Mody4, anticorps proinsulin, anticorps zgc:109842, anticorps igf2-A, anticorps ins, anticorps ins-a, anticorps ins-b, anticorps insulin, anticorps insulin precursor, anticorps insulin II, anticorps preproinsulin, anticorps insulin L homeolog, anticorps insulin S homeolog, anticorps INS, anticorps INS-IGF2, anticorps ins, anticorps Ins, anticorps PIN, anticorps Ins2, anticorps ins.L, anticorps ins.S
    Sujet
    IDDM2, ILPR, IRDN, MODY10, Proinsulin
    Poids moléculaire
    6 kDa
    ID gène
    3630, 272259
    UniProt
    P01308
    Pathways
    Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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