CDC25B anticorps (pSer149)

N° du produit ABIN616043

Détail du produit anti-CDC25B anticorps

Antigène: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Épitope: pSer149

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC25B est non-conjugé

Application: Western Blotting (WB)

Séquence: F-R-S(p)-L-P

Specificité: This antibody detects endogenous level of Cdc25B protein only when phosphorylated at serine 149.

Réactivité croisée (Details): Species reactivity (tested):Mouse, rat

Purification: Affinity-chromatography using epitope-specific peptide

Immunogène: Peptide sequence around phosphorylation site of Serine 149 derived from Mouse Cdc25B.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur CDC25B

Antigène: CDC25B (Cell Division Cycle 25 Homolog B (S. Pombe) (CDC25B))

Autre désignation: Cdc25B (CDC25B Produits)

Synonymes: anticorps CDC25B, anticorps AI604853, anticorps cell division cycle 25B, anticorps cdc25b, anticorps CDC25B, anticorps Cdc25b

Sujet: Cdc25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.

ID gène: 12531

NCBI Accession: NP_001104545

UniProt: Q9DBN8

Pathways: Cycle Cellulaire, M Phase, Autophagy