FOXP3 anticorps (CF®640R)
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- Antigène Voir toutes FOXP3 Anticorps
- FOXP3 (Forkhead Box P3 (FOXP3))
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Reactivité
- Humain, Souris, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FOXP3 est conjugé à/à la CF®640R
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Fonction
- Mouse Monoclonal anti-FOXP3 (FXP3/197), CF640R Conjugate
- Attributs du produit
- This antibody recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Recombinant human full-length FOXP3 protein
- Clone
- FXP3-197
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product FOXP3 Anticorps primaire
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- Indications d'application
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Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris buffer with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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Tonsil or Testis
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
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- Antigène
- FOXP3 (Forkhead Box P3 (FOXP3))
- Autre désignation
- FOXP3 (FOXP3 Produits)
- Synonymes
- anticorps foxp3, anticorps FOXP3, anticorps AIID, anticorps DIETER, anticorps IPEX, anticorps PIDX, anticorps XPID, anticorps JM2, anticorps scurfin, anticorps sf, anticorps RGD1562112, anticorps forkhead box P3, anticorps forkhead box P3a, anticorps forkhead box P3 L homeolog, anticorps FOXP3, anticorps foxp3a, anticorps foxp3, anticorps foxp3.L, anticorps Foxp3
- Poids moléculaire
- 47-55 kDa
- ID gène
- 50943, 247700
- UniProt
- Q9BZS1
- Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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