TOX3 anticorps (AA 200-400)

N° du produit ABIN6167778

Détail du produit anti-TOX3 anticorps

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Épitope: AA 200-400

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Fonction: Mouse Monoclonal anti-TOX3 (TOX3/1123), Purified, BSA-free

Attributs du produit: This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Purification: Purified

Immunogène: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein

Clone: TOX3-1123

Isotype: IgG2b kappa

Information d'application

Indications d'application: Immunohistology formalin-fixed 0.5-1 μg/mL

• Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA,  pH 9.0 or 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
• Immunofluorescence 0.5-1 μg/mL
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS (no BSA, no azide)

Agent conservateur: Azide free

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX3 (TOX3 Produits)

Synonymes: anticorps TNRC9, anticorps cagf9, anticorps tnrc9, anticorps CAGF9, anticorps 500-9, anticorps BC052044, anticorps C230068E13, anticorps Tnrc9, anticorps TOX high mobility group box family member 3, anticorps TOX3, anticorps tox3, anticorps Tox3

Sujet: TOX3, CAG trinucleotide repeat-containing gene F9 protein, CAGF9, TOX high mobility group box family member 3, Trinucleotide repeat containing 9 (TNRC9)

Poids moléculaire: 63 kDa

ID gène: 27324, 460789

UniProt: O15405

Pathways: Chromatin Binding