CDKN2A anticorps (pSer140)

N° du produit ABIN6241061

Détail du produit anti-CDKN2A anticorps

Antigène: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Épitope: pSer140

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This p16-INK4A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p16-INK4A.

Clone: RB21280

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CDKN2A (ABIN6241061)

Al-Khalaf, Hendrayani, Aboussekhra: "The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation." dans: Molecular cancer research : MCR, Vol. 9, Issue 3, pp. 311-9, (2011) (PubMed).

Détails sur CDKN2A

Antigène: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Autre désignation: p16-INK4A (CDKN2A Produits)

Synonymes: anticorps Arf, anticorps p16, anticorps MTS1, anticorps INK4A, anticorps p19ARF, anticorps p16Cdkn2a, anticorps ARF, anticorps CDK4I, anticorps CDKN2, anticorps CMM2, anticorps INK4, anticorps MLM, anticorps MTS-1, anticorps P14, anticorps P14ARF, anticorps P16, anticorps P16-INK4A, anticorps P16INK4, anticorps P16INK4A, anticorps P19, anticorps P19ARF, anticorps TP16, anticorps ARF-INK4a, anticorps INK4a-ARF, anticorps Ink4a/Arf, anticorps Pctr1, anticorps p16(INK4a), anticorps p16INK4a, anticorps p19, anticorps cyclin-dependent kinase inhibitor 2A, anticorps cyclin dependent kinase inhibitor 2A, anticorps Cdkn2a, anticorps LOC100731972, anticorps LOC100340625, anticorps CDKN2A

Sujet: P16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Poids moléculaire: 16533

NCBI Accession: NP_000068, NP_001182061, NP_478104

UniProt: P42771

Pathways: Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus