ACER2 anticorps

N° du produit ABIN6241552

Détail du produit anti-ACER2 anticorps

Antigène: ACER2 (Alkaline Ceramidase 2 (ACER2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACER2 est non-conjugé

Application: Western Blotting (WB)

Immunogène: Synthetic Peptide

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détails sur ACER2

Antigène: ACER2 (Alkaline Ceramidase 2 (ACER2))

Autre désignation: ASAH3L (ACER2 Produits)

Synonymes: anticorps ASAH3L, anticorps asah3l, anticorps ALKCDase2, anticorps 2410116I05Rik, anticorps Asah3l, anticorps CRG-L1, anticorps maCER2, anticorps alkaline ceramidase 2, anticorps alkaline ceramidase 2 S homeolog, anticorps ACER2, anticorps acer2.S, anticorps acer2, anticorps Acer2

Sujet: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

UniProt: Q5QJU3

Pathways: Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process