TAP2 anticorps (AA 100-134)
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- Antigène Voir toutes TAP2 Anticorps
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
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Épitope
- AA 100-134
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAP2 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This TAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 100-134 amino acids from the human region of human TAP2.
- Clone
- RB56970
- Isotype
- Ig Fraction
- Top Product
- Discover our top product TAP2 Anticorps primaire
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- Indications d'application
- WB: 1:2000. FC: 1:25
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Date de péremption
- 6 months
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- Antigène
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
- Autre désignation
- TAP2 (TAP2 Produits)
- Synonymes
- anticorps ABC18, anticorps ABCB3, anticorps APT2, anticorps D6S217E, anticorps PSF-2, anticorps PSF2, anticorps RING11, anticorps AI462429, anticorps Abcb3, anticorps Ham-2, anticorps Ham2, anticorps MTP2, anticorps Tap-2, anticorps Y1, anticorps jas, anticorps Cim, anticorps transporter 2, ATP binding cassette subfamily B member, anticorps transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), anticorps TAP2, anticorps Tap2
- Sujet
- Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
- Poids moléculaire
- 75664
- UniProt
- Q03519
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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