TAP2 anticorps (AA 473-615)

N° du produit ABIN7144329

Détail du produit anti-TAP2 anticorps

Antigène: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Épitope: AA 473-615

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAP2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Antigen peptide transporter 2 protein (473-615AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TAP2

Antigène: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Autre désignation: TAP2 (TAP2 Produits)

Synonymes: anticorps ABC18, anticorps ABCB3, anticorps APT2, anticorps D6S217E, anticorps PSF-2, anticorps PSF2, anticorps RING11, anticorps AI462429, anticorps Abcb3, anticorps Ham-2, anticorps Ham2, anticorps MTP2, anticorps Tap-2, anticorps Y1, anticorps jas, anticorps Cim, anticorps transporter 2, ATP binding cassette subfamily B member, anticorps transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), anticorps TAP2, anticorps Tap2

Sujet:

Background: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Aliases: ABC transporter, MHC 2 antibody, ABC18 antibody, ABCB3 antibody, Antigen peptide transporter 2 antibody, APT2 antibody, ATP binding cassette, sub family B (MDR/TAP), member 3 antibody, ATP-binding cassette sub-family B member 3 antibody, D6S217E antibody, Peptide supply factor 2 antibody, Peptide transporter involved in antigen processing 2 antibody, Peptide transporter PSF2 antibody, Peptide transporter TAP2 antibody, PSF 2 antibody, PSF-2 antibody, PSF2 antibody, Really interesting new gene 11 protein antibody, RING 11 antibody, RING11 antibody, TAP 2 antibody, Tap2 antibody, TAP2_HUMAN antibody, Transporter 2 ATP binding cassette sub family B antibody, Transporter 2, ABC (ATP binding cassette antibody, Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody

UniProt: Q03519

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process