TGF-beta anticorps

N° du produit ABIN6252537

Détail du produit anti-TGF-beta anticorps

Antigène: TGF-beta (TGFb)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Hamster, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TGF-beta est non-conjugé

Application: Neutralization (Neut)

Purification: Protein G affinity chromatography

Immunogène: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Clone: 1D11-16-8

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional Activity: Cytokine Neutralization (Order SAF formulation)

Optimal dilution of the TGF-beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur TGF-beta

Antigène: TGF-beta (TGFb)

Autre désignation: TGF-beta (TGFb Produits)

Synonymes: anticorps CED, anticorps DPD1, anticorps LAP, anticorps TGFB, anticorps TGFbeta, anticorps TGF-beta, anticorps TGF-BETA-1, anticorps TGF-beta1, anticorps TGFbeta1, anticorps Tgfb, anticorps Tgfb-1, anticorps transforming growth factor beta 1, anticorps transforming growth factor beta-1, anticorps transforming growth factor, beta 1, anticorps TGFB1, anticorps Tgfb1

Sujet: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

ID gène: 7040, 7043, 7042

UniProt: P01137, P10600, P61812

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus