CD13 anticorps

N° du produit ABIN6252577

Détail du produit anti-CD13 anticorps

Antigène: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD13 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Protein G affinity chromatography

Immunogène: KG-1 myeloid cells were used as the immunogen for the CD13 antibody.

Clone: B-F10

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml

Immunofluorescence: 1-2 μg/mL

Immunohistochemistry (Frozen): 0.5-1 μg/mL for 30 min at RT

Optimal dilution of the CD13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Détails sur CD13

Antigène: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Autre désignation: CD13 (ANPEP Produits)

Synonymes: anticorps APN, anticorps CD13, anticorps GP150, anticorps LAP1, anticorps P150, anticorps PEPN, anticorps A2AP, anticorps AAP, anticorps ALPHA-2-PI, anticorps API, anticorps PLI, anticorps AAT1, anticorps ALT1, anticorps GPT1, anticorps Gpt1, anticorps Apn, anticorps pepN, anticorps SC8E4A.13, anticorps 1300007J06Rik, anticorps 2310022B03Rik, anticorps ALT, anticorps Gpt-1, anticorps AP-M, anticorps AP-N, anticorps Cd13, anticorps Apm, anticorps KZP, anticorps Lap1, anticorps rAPN, anticorps APDE, anticorps p150, anticorps anpep, anticorps fb64c05, anticorps wu:fb64c05, anticorps zgc:136771, anticorps alanyl aminopeptidase, membrane, anticorps serpin family F member 2, anticorps glutamic--pyruvic transaminase, anticorps aminopeptidase N, anticorps aminopeptidase, anticorps aminopeptidase n, anticorps glutamic pyruvic transaminase, soluble, anticorps alanyl (membrane) aminopeptidase, anticorps membrane alanyl aminopeptidase, anticorps alanyl (membrane) aminopeptidase b, anticorps alanyl aminopeptidase, membrane L homeolog, anticorps ANPEP, anticorps SERPINF2, anticorps GPT, anticorps Gpt, anticorps Apn2, anticorps Apn1, anticorps SCO2643, anticorps pepN, anticorps Shewana3_0897, anticorps Alvin_1024, anticorps Ndas_3413, anticorps Saut_1544, anticorps Fbal_1877, anticorps ML5_3424, anticorps Despr_1988, anticorps Mesop_5365, anticorps Anpep, anticorps LOC101744250, anticorps anpepb, anticorps anpep.L

Sujet: Recognizes an integral membrane glycoprotein of 150  kDa, identified as CD13 (also known as aminopeptidase-N). The CD13 antigen is present on most cells of myeloid origin including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes, platelets and erythrocytes. CD13 is also present on fibroblasts, endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN), a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides, in phagocytosis, and in bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.

ID gène: 290

UniProt: P15144

Pathways: Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones