CD31 anticorps (pTyr713)
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- Antigène Voir toutes CD31 (PECAM1) Anticorps
- CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
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Épitope
- pTyr713
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CD31 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
- Specificité
- Phospho-CD31 (Tyr713) Antibody detects endogenous levels of CD31 only when phosphorylated at Tyrosine 713.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogène
- A synthesized peptide derived from human CD31 around the phosphorylation site of Tyr713.
- Isotype
- IgG
- Top Product
- Discover our top product PECAM1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))
- Autre désignation
- PECAM1 (PECAM1 Produits)
- Synonymes
- anticorps CD31, anticorps CD31/EndoCAM, anticorps GPIIA', anticorps PECA1, anticorps PECAM-1, anticorps endoCAM, anticorps C85791, anticorps Cd31, anticorps Pecam, anticorps platelet/endothelial cell adhesion molecule 1, anticorps platelet and endothelial cell adhesion molecule 1, anticorps pecam1, anticorps PECAM1, anticorps Pecam1
- Sujet
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Description: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).
Gene: PECAM1
- Poids moléculaire
- 82/150kDa
- ID gène
- 5175
- UniProt
- P16284
- Pathways
- Regulation of Actin Filament Polymerization
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