RICTOR anticorps (pThr1135)

N° du produit ABIN6256465

Cet anticorps anti-RICTOR Polyclonal Lapin (ABIN6256465) détecte spécifiquement RICTOR dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour RICTOR anticorps (pThr1135) (ABIN6256465)

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RICTOR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-RICTOR anticorps

Épitope: pThr1135

Specificité: Phospho-Rictor (Thr1135) Antibody detects endogenous levels of Rictor.

Réactivité croisée: Humain, Souris

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogène: A synthesized peptide derived from human Rictor around the phosphorylation site of Thr1135.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur RICTOR

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Autre désignation: Rictor

Sujet:

Description: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Gene: RICTOR

Poids moléculaire: 200kDa

ID gène: 253260

UniProt: Q6R327

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events