RICTOR anticorps (AA 1-245)

N° du produit ABIN7167113

Détail du produit anti-RICTOR anticorps

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Épitope: AA 1-245

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RICTOR est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Rapamycin-insensitive companion of mTOR protein (1-245AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RICTOR

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Autre désignation: RICTOR (RICTOR Produits)

Synonymes: anticorps PIA, anticorps mAVO3, anticorps 4921505C17Rik, anticorps 6030405M08Rik, anticorps AVO3, anticorps AW492497, anticorps D530039E11Rik, anticorps Fyb, anticorps RPTOR independent companion of MTOR complex 2, anticorps RPTOR independent companion of MTOR, complex 2, anticorps RICTOR, anticorps Rictor

Sujet:

Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Plays an essential role in embryonic growth and development.

Aliases: AVO3 antibody, AVO3 homolog antibody, DKFZp686B11164 antibody, hAVO3 antibody, KIAA1999 antibody, Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody, mAVO3 antibody, MGC39830 antibody, PIA antibody, Pianissimo antibody, Rapamycin insensitive companion of mTOR antibody, Rapamycin-insensitive companion of mTOR antibody, Rictor antibody, RICTR antibody, RICTR_HUMAN antibody, RPTOR independent companion of MTOR complex 2 antibody, TORC2 specific protein AVO3 antibody

UniProt: Q6R327

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events