EPHA1 anticorps (Internal Region)
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- Antigène Voir toutes EPHA1 Anticorps
- EPHA1 (Ephrin Type A Receptor 1 (EPHA1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EPHA1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- EPHA1 Antibody detects endogenous levels of total EPHA1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human EPHA1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product EPHA1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- EPHA1 (Ephrin Type A Receptor 1 (EPHA1))
- Autre désignation
- EPHA1 (EPHA1 Produits)
- Synonymes
- anticorps EPH, anticorps EPHT, anticorps EPHT1, anticorps 5730453L17Rik, anticorps AL033318, anticorps Eph, anticorps Esk, anticorps EPHA9, anticorps EPH receptor A1, anticorps Eph receptor A1, anticorps EPHA1, anticorps Epha1
- Sujet
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Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Gene: EPHA1
- Poids moléculaire
- 108 kDa
- ID gène
- 2041
- UniProt
- P21709
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