VPS4B anticorps (Internal Region)

N° du produit ABIN6258436

Détail du produit anti-VPS4B anticorps

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS4B est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: VPS4B Antibody detects endogenous levels of total VPS4B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human VPS4B, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Date de péremption: 12 months

Détails sur VPS4B

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Autre désignation: VPS4B (vps4b Produits)

Synonymes: anticorps zgc:63682, anticorps vps4a, anticorps SKD1, anticorps SKD1B, anticorps VPS4-2, anticorps 8030489C12Rik, anticorps Skd1, anticorps vacuolar protein sorting 4 homolog B, anticorps vacuolar protein sorting 4 homolog B S homeolog, anticorps vacuolar protein sorting 4b homolog B (S. cerevisiae), anticorps vacuolar protein sorting 4 homolog B (S. cerevisiae), anticorps vacuolar protein sorting 4B, anticorps Vps4b, anticorps vps4b.S, anticorps vps4b, anticorps VPS4B

Sujet:

Description: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Gene: VPS4B

Poids moléculaire: 49 kDa

ID gène: 9525

UniProt: O75351

Pathways: Dynamique des Microtubules, CXCR4-mediated Signaling Events