GLRB anticorps (Internal Region)

N° du produit ABIN6258906

Détail du produit anti-GLRB anticorps

Antigène: GLRB (Glycine Receptor, beta (GLRB))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLRB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: GLRB Antibody detects endogenous levels of total GLRB.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GLRB, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GLRB

Antigène: GLRB (Glycine Receptor, beta (GLRB))

Autre désignation: GLRB (GLRB Produits)

Synonymes: anticorps HKPX2, anticorps glrb, anticorps MGC145156, anticorps AI853901, anticorps Glyrb, anticorps spa, anticorps spastic, anticorps glrb2, anticorps zgc:101041, anticorps glycine receptor beta, anticorps glycine receptor, beta, anticorps glycine receptor, beta subunit, anticorps glycine receptor, beta b, anticorps GLRB, anticorps Glrb, anticorps glrb, anticorps glrbb

Sujet:

Description: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Gene: GLRB

Poids moléculaire: 56 kDa

ID gène: 2743

UniProt: P48167