Angiopoietin 1 anticorps (Internal Region)

N° du produit ABIN6259926

Détail du produit anti-Angiopoietin 1 anticorps

Antigène: Angiopoietin 1 (ANGPT1)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiopoietin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: Angiopoietin 1 Antibody detects endogenous levels of total Angiopoietin 1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Angiopoietin 1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-Angiopoietin 1 (ABIN6259926)

Wu, Hu, Yin, Li, Zhang: "[Dose and timing of normal saline resuscitation on endothelial glycocalyx in early septic shock]." dans: Zhonghua wei zhong bing ji jiu yi xue, Vol. 30, Issue 7, pp. 629-634, (2018) (PubMed).

Détails sur Angiopoietin 1

Antigène: Angiopoietin 1 (ANGPT1)

Autre désignation: ANGPT1 (ANGPT1 Produits)

Synonymes: anticorps AGP1, anticorps AGPT, anticorps ANG1, anticorps 1110046O21Rik, anticorps Ang-1, anticorps Ang1, anticorps Agpt, anticorps Agpt1, anticorps ang1, anticorps wu:fc76g06, anticorps ANG-1, anticorps angpt1, anticorps MGC80788, anticorps angiopoietin 1, anticorps angiopoietin 1 S homeolog, anticorps ANGPT1, anticorps Angpt1, anticorps angpt1, anticorps angpt1.S

Sujet:

Description: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Gene: ANGPT1

Poids moléculaire: 57 kDa

ID gène: 284

UniProt: Q15389

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process