Beclin 1 anticorps (Internal Region)

N° du produit ABIN6260248

Détail du produit anti-Beclin 1 anticorps

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Beclin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Beclin 1 Antibody detects endogenous levels of total Beclin 1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Beclin 1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-Beclin 1 (ABIN6260248)

Wu, Zheng, Bai, Xia, Zhang, Guo: "HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma." dans: OncoTargets and therapy, Vol. 11, pp. 4501-4510, (2018) (PubMed).

Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." dans: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, (2017) (PubMed).

Détails sur Beclin 1

Antigène: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Autre désignation: BECN1 (BECN1 Produits)

Synonymes: anticorps beclin-1, anticorps atg6, anticorps vps30, anticorps beclin1, anticorps Beclin-1, anticorps becn1, anticorps zgc:73097, anticorps ATG6, anticorps VPS30, anticorps 4921513J16Rik, anticorps 5430417M23Rik, anticorps Atg6, anticorps beclin 1, anticorps beclin 1, autophagy related, anticorps beclin 1 protein, anticorps beclin-1, anticorps beclin family protein, anticorps beclin 1, autophagy related L homeolog, anticorps BECN1, anticorps becn1, anticorps atg6, anticorps CpipJ_CPIJ011087, anticorps PTRG_07825, anticorps SJAG_01876, anticorps Becn1, anticorps becn1.L

Sujet:

Description: Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Gene: BECN1

Poids moléculaire: 52 kDa

ID gène: 8678

UniProt: Q14457

Pathways: Autophagy