BRSK2 anticorps (Internal Region)

N° du produit ABIN6260317

Détail du produit anti-BRSK2 anticorps

Antigène: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRSK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: BRSK2 Antibody detects endogenous levels of total BRSK2.

Homologie: Pig,Bovine,Horse,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human BRSK2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur BRSK2

Antigène: BRSK2 (BR serine/threonine Kinase 2 (BRSK2))

Autre désignation: BRSK2 (BRSK2 Produits)

Synonymes: anticorps C11orf7, anticorps PEN11B, anticorps SAD1, anticorps SADA, anticorps STK29, anticorps BRSK2, anticorps 4833424K13Rik, anticorps SAD-A, anticorps BR serine/threonine kinase 2, anticorps BRSK2, anticorps Brsk2

Sujet:

Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

Gene: BRSK2

Poids moléculaire: 82 kDa

ID gène: 9024

UniProt: Q8IWQ3