CBX2 anticorps (Internal Region)

N° du produit ABIN6260519

Détail du produit anti-CBX2 anticorps

Antigène: CBX2 (Chromobox Homolog 2 (CBX2))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: CBX2 Antibody detects endogenous levels of total CBX2.

Homologie: Pig,Bovine,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CBX2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CBX2

Antigène: CBX2 (Chromobox Homolog 2 (CBX2))

Autre désignation: CBX2 (CBX2 Produits)

Synonymes: anticorps cbx2, anticorps M33, anticorps pc1, anticorps wu:fd20e09, anticorps zgc:103563, anticorps MOD2, anticorps pc, anticorps CDCA6, anticorps SRXY5, anticorps cdca6, anticorps m33, anticorps chromobox 2, anticorps chromobox homolog 2 (Drosophila Pc class), anticorps chromobox 2 L homeolog, anticorps cbx2, anticorps CBX2, anticorps Cbx2, anticorps cbx2.L

Sujet:

Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).

Gene: CBX2

Poids moléculaire: 56 kDa

ID gène: 84733

UniProt: Q14781