CNOT1 anticorps (Internal Region)
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- Antigène Voir toutes CNOT1 Anticorps
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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Épitope
- Internal Region
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CNOT1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- CNOT1 Antibody detects endogenous levels of total CNOT1.
- Homologie
- Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human CNOT1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CNOT1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Autre désignation
- CNOT1 (CNOT1 Produits)
- Synonymes
- anticorps CDC39, anticorps NOT1, anticorps NOT1H, anticorps 6030411K04Rik, anticorps AA815922, anticorps D830048B13, anticorps RGD1308009, anticorps GB18988, anticorps cdc39-like, anticorps im:7141761, anticorps kiaa1007l, anticorps wu:fc58h04, anticorps zgc:152902, anticorps CNOT1, anticorps not1, anticorps cdc39, anticorps not1h, anticorps ad-005, anticorps NV18106, anticorps CCR4-NOT transcription complex subunit 1, anticorps CCR4-NOT transcription complex, subunit 1, anticorps CNOT1, anticorps Cnot1, anticorps LOC412371, anticorps cnot1, anticorps LOC100114396
- Sujet
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Description: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Gene: CNOT1
- Poids moléculaire
- 240-250 kDa,174 kDa
- ID gène
- 23019
- UniProt
- A5YKK6
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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