COPS5 anticorps (Internal Region)

N° du produit ABIN6260970

Détail du produit anti-COPS5 anticorps

Antigène: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: COPS5 Antibody detects endogenous levels of total COPS5.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human COPS5, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur COPS5

Antigène: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Autre désignation: COPS5 (COPS5 Produits)

Synonymes: anticorps BcDNA.LD14392, anticorps BcDNA:LD14392, anticorps CG14884, anticorps CH5, anticorps CSN-5, anticorps Csn5, anticorps DCH5, anticorps Dch5, anticorps Dmel\\CG14884, anticorps JAB1, anticorps JAB1/CSN5, anticorps Jab1, anticorps JadBp, anticorps csn5, anticorps dch5, anticorps jab1/csn5, anticorps l(3)89Cf, anticorps l(3)L4032, anticorps l(3)M203, anticorps quo, anticorps COPS5, anticorps MGC76063, anticorps AI303502, anticorps CSN5, anticorps Mov34, anticorps Sgn5, anticorps zgc:73130, anticorps MOV-34, anticorps SGN5, anticorps COP9 signalosome subunit 5, anticorps COP9 signalosome complex subunit 5, anticorps COP9 signalosome subunit 5 S homeolog, anticorps CSN5, anticorps COPS5, anticorps cops5, anticorps CpipJ_CPIJ012314, anticorps Bm1_46585, anticorps VDBG_06932, anticorps LOAG_01443, anticorps csn5, anticorps Cops5, anticorps cops5.S, anticorps csn-5

Sujet:

Description: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Gene: COPS5

Poids moléculaire: 37kDa

ID gène: 10987

UniProt: Q92905

Pathways: Cycle Cellulaire