CPSF6 anticorps (Internal Region)
-
- Antigène Voir toutes CPSF6 Anticorps
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
-
Épitope
- Internal Region
-
Reactivité
- Humain, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp CPSF6 est non-conjugé
-
Application
- Western Blotting (WB), ELISA
- Specificité
- CPSF6 Antibody detects endogenous levels of total CPSF6.
- Homologie
- Bovine,Horse,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CPSF6 Anticorps primaire
-
-
- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
- Autre désignation
- CPSF6 (CPSF6 Produits)
- Synonymes
- anticorps CPSF6, anticorps wu:fa22f12, anticorps zgc:85819, anticorps 4733401N12Rik, anticorps AI256641, anticorps CFIM, anticorps CFIM68, anticorps HPBRII-4, anticorps HPBRII-7, anticorps cleavage and polyadenylation specific factor 6, anticorps cleavage and polyadenylation specific factor 6 S homeolog, anticorps CPSF6, anticorps cpsf6.S, anticorps cpsf6, anticorps Cpsf6
- Sujet
-
Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).
Gene: CPSF6
- Poids moléculaire
- 59 kDa
- ID gène
- 11052
- UniProt
- Q16630
-