CYR61 anticorps (Internal Region)

N° du produit ABIN6261175

Détail du produit anti-CYR61 anticorps

Antigène: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYR61 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CYR61/CCN1 Antibody detects endogenous levels of total CYR61/CCN1.

Homologie: Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CYR61/CCN1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CYR61

Antigène: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))

Autre désignation: CYR61 (CYR61 Produits)

Synonymes: anticorps CCN1, anticorps GIG1, anticorps IGFBP10, anticorps ccn1, anticorps gig1, anticorps Xcyr61, anticorps igfbp10, anticorps MGC69281, anticorps MGC69539, anticorps cyr61-l2, anticorps zgc:158158, anticorps CYR61, anticorps AI325051, anticorps Igfbp10, anticorps cysteine rich angiogenic inducer 61, anticorps cysteine-rich, angiogenic inducer, 61, anticorps cysteine-rich, angiogenic inducer, 61 like 2, anticorps cysteine rich protein 61, anticorps cysteine rich angiogenic inducer 61 S homeolog, anticorps CYR61, anticorps Cyr61, anticorps cyr61, anticorps cyr61l2, anticorps cyr61.S

Sujet:

Description: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Gene: CYR61

Poids moléculaire: 42kDa

ID gène: 3491

UniProt: O00622

Pathways: Positive Regulation of Endopeptidase Activity, Growth Factor Binding