DACH1 anticorps (Internal Region)

N° du produit ABIN6261216

Détail du produit anti-DACH1 anticorps

Antigène: DACH1 (Dachshund 1 (DACH1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: DACH1 Antibody detects endogenous levels of total DACH1.

Homologie: Pig,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DACH1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DACH1

Antigène: DACH1 (Dachshund 1 (DACH1))

Autre désignation: DACH1 (DACH1 Produits)

Synonymes: anticorps DACH, anticorps AI182278, anticorps Dac, anticorps Dach, anticorps E130112M23Rik, anticorps dach, anticorps dachshund family transcription factor 1, anticorps dachshund 1 (Drosophila), anticorps dachshund family transcription factor 1 S homeolog, anticorps dachshund homolog 1, anticorps DACH1, anticorps Dach1, anticorps dach1.S, anticorps dach1, anticorps LOC100550020

Sujet:

Description: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Gene: DACH1

Poids moléculaire: 97-100 kDa

ID gène: 1602

UniProt: Q9UI36

Pathways: Feeding Behaviour