DCLRE1B anticorps (Internal Region)

N° du produit ABIN6261237

Détail du produit anti-DCLRE1B anticorps

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLRE1B est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: DCLRE1B Antibody detects endogenous levels of total DCLRE1B.

Homologie: Pig,Bovine,Horse,Sheep

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DCLRE1B, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DCLRE1B

Antigène: DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))

Autre désignation: DCLRE1B (DCLRE1B Produits)

Synonymes: anticorps APOLLO, anticorps SNM1B, anticorps SNMIB, anticorps im:6894074, anticorps zgc:154089, anticorps AI452214, anticorps Apollo, anticorps mSNM1B, anticorps DNA cross-link repair 1B, anticorps DCLRE1B, anticorps Dclre1b, anticorps dclre1b

Sujet:

Description: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

Gene: DCLRE1B

Poids moléculaire: 60 kDa

ID gène: 64858

UniProt: Q9H816