DDX21 anticorps (Internal Region)

N° du produit ABIN6261252

Détail du produit anti-DDX21 anticorps

Antigène: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDX21 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: DDX21 Antibody detects endogenous levels of total DDX21.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DDX21, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DDX21

Antigène: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Autre désignation: DDX21 (DDX21 Produits)

Synonymes: anticorps MGC130693, anticorps DDX21, anticorps cb960, anticorps wu:fi30c07, anticorps wu:fi34d08, anticorps GUA, anticorps GURDB, anticorps RH-II/GU, anticorps RH-II/GuA, anticorps Ddx21a, anticorps AI255159, anticorps AL022742, anticorps D10Ertd645e, anticorps D10Wsu42e, anticorps DEAD-box helicase 21 L homeolog, anticorps DExD-box helicase 21, anticorps DEAD-box helicase 21, anticorps DEAD (Asp-Glu-Ala-Asp) box helicase 21, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 21, anticorps ddx21.L, anticorps DDX21, anticorps ddx21, anticorps Ddx21

Sujet:

Description: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233).

Gene: DDX21

Poids moléculaire: 87 kDa

ID gène: 9188

UniProt: Q9NR30

Pathways: SARS-CoV-2 Protein Interactome