EPH Receptor A8 anticorps (Internal Region)

N° du produit ABIN6261567

Détail du produit anti-EPH Receptor A8 anticorps

Antigène: EPH Receptor A8 (EPHA8)

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A8 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: EPHA8 Antibody detects endogenous levels of total EPHA8.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EPHA8, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EPH Receptor A8

Antigène: EPH Receptor A8 (EPHA8)

Autre désignation: EPHA8 (EPHA8 Produits)

Synonymes: anticorps TK, anticorps tke17-a, anticorps si:ch211-122l14.1, anticorps EPHA8, anticorps EEK, anticorps EK3, anticorps HEK3, anticorps AW047546, anticorps Eek, anticorps Hek3, anticorps mKIAA1459, anticorps EPH receptor A8 L homeolog, anticorps EPH receptor A8, anticorps eph receptor A8, anticorps Eph receptor A8, anticorps epha8.L, anticorps EPHA8, anticorps epha8, anticorps Epha8

Sujet:

Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Gene: EPHA8

Poids moléculaire: 111kDa.

ID gène: 2046

UniProt: P29322

Pathways: Signalisation RTK