FBXW7 anticorps
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- Antigène Voir toutes FBXW7 Anticorps
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXW7 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- FBXW7 antibody detects endogenous levels of FBXW7.
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human FBXW7.
- Isotype
- IgG
- Top Product
- Discover our top product FBXW7 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Autre désignation
- FBXW7 (FBXW7 Produits)
- Synonymes
- anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7
- Sujet
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Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:29149593, PubMed:25775507). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593).
Gene: FBXW7
- Poids moléculaire
- 60-65 kDa
- ID gène
- 55294
- UniProt
- Q969H0
- Pathways
- Signalisation Notch, EGFR Signaling Pathway
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