FZD5 anticorps (C-Term)

N° du produit ABIN6261840

Détail du produit anti-FZD5 anticorps

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD5 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: FZD5 Antibody detects endogenous levels of total FZD5.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human FZD5, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur FZD5

Antigène: FZD5 (Frizzled Family Receptor 5 (FZD5))

Autre désignation: FZD5 (FZD5 Produits)

Synonymes: anticorps C2orf31, anticorps HFZ5, anticorps 5330434N09Rik, anticorps AI427138, anticorps Fz-5, anticorps Fz5, anticorps mFz5, anticorps Xfz5, anticorps frizzled5, anticorps frizzled5a, anticorps fz5, anticorps fzd5-A, anticorps fz2, anticorps fz8c, anticorps fzd8c, anticorps zg02, anticorps frizzled class receptor 5, anticorps frizzled class receptor 5 S homeolog, anticorps FZD5, anticorps Fzd5, anticorps fzd5.S, anticorps fzd5

Sujet:

Description: Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro), the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).

Gene: FZD5

Poids moléculaire: 64 kDa

ID gène: 7855

UniProt: Q13467

Pathways: Signalisation WNT