IKZF1 anticorps (Internal Region)

N° du produit ABIN6262519

Détail du produit anti-IKZF1 anticorps

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKZF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: IKZF1 Antibody detects endogenous levels of total IKZF1.

Homologie: Pig,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IKZF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur IKZF1

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Autre désignation: IKZF1 (IKZF1 Produits)

Synonymes: anticorps Hs.54452, anticorps IK1, anticorps IKAROS, anticorps LYF1, anticorps PRO0758, anticorps ZNFN1A1, anticorps hIk-1, anticorps RGD1562979, anticorps ikaros, anticorps znfn1a1, anticorps ik1, anticorps lyf1, anticorps hik-1, anticorps pro0758, anticorps hs.54452, anticorps MGC108252, anticorps 5832432G11Rik, anticorps Ikaros, anticorps LyF-1, anticorps Zfpn1a1, anticorps Znfn1a1, anticorps hlk-1, anticorps mKIAA4227, anticorps ikzf1, anticorps IKAROS family zinc finger 1, anticorps IKAROS family zinc finger 1 (Ikaros), anticorps IKZF1, anticorps Ikzf1, anticorps ikzf1

Sujet:

Description: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

Gene: IKZF1

Poids moléculaire: 53kDa

ID gène: 10320

UniProt: Q13422

Pathways: Production of Molecular Mediator of Immune Response