KCNMA1 anticorps (Internal Region)
-
- Antigène Voir toutes KCNMA1 Anticorps
- KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))
-
Épitope
- Internal Region
-
Reactivité
- Humain, Rat, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp KCNMA1 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- MaxiK alpha Antibody detects endogenous levels of total MaxiK alpha.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human MaxiK alpha, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product KCNMA1 Anticorps primaire
-
-
- Indications d'application
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))
- Autre désignation
- KCNMA1 (KCNMA1 Produits)
- Synonymes
- anticorps BKTM, anticorps KCa1.1, anticorps MaxiK, anticorps SAKCA, anticorps SLO, anticorps SLO-ALPHA, anticorps SLO1, anticorps bA205K10.1, anticorps mSLO1, anticorps DDBDRAFT_0190653, anticorps DDBDRAFT_0235401, anticorps DDB_0190653, anticorps DDB_0235401, anticorps KCNMA, anticorps KCNMA1, anticorps 5730414M22Rik, anticorps BKCa, anticorps Slo, anticorps Slo1, anticorps mSlo, anticorps mSlo1, anticorps KCNMA1b, anticorps KCNMA1c, anticorps Kcnma, anticorps bktm, anticorps kcnma1-A, anticorps sakca, anticorps cSlo, anticorps slo1, anticorps kcnma1, anticorps si:ch211-39f22.2, anticorps BcDNA:GH10751, anticorps CG10693, anticorps Dmel\CG10693, anticorps Dslo, anticorps dSlo, anticorps dSlo1, anticorps dslo, anticorps fSlo, anticorps potassium calcium-activated channel subfamily M alpha 1, anticorps calcium-activated BK potassium channel, alpha subunit, anticorps potassium large conductance calcium-activated channel, subfamily M, alpha member 1, anticorps potassium calcium-activated channel subfamily M alpha 1 L homeolog, anticorps potassium large conductance calcium-activated channel, subfamily M, alpha member 1a, anticorps calcium-activated potassium channel subunit alpha-1, anticorps slowpoke, anticorps KCNMA1, anticorps kcnma1, anticorps Kcnma1, anticorps kcnma1.L, anticorps kcnma1a, anticorps LOC100454095, anticorps slo
- Sujet
-
Description: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Gene: KCNMA1
- Poids moléculaire
- 137 kDa
- ID gène
- 3778
- UniProt
- Q12791
- Pathways
- Regulation of Hormone Metabolic Process, Sensory Perception of Sound
-