MAP4K6 anticorps (Internal Region)

N° du produit ABIN6263255

Détail du produit anti-MAP4K6 anticorps

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: MINK1 Antibody detects endogenous levels of total MINK1.

Homologie: Pig,Zebrafish,Bovine,Horse,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MINK1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MAP4K6

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Autre désignation: MINK1 (MINK1 Produits)

Synonymes: anticorps MINK1, anticorps MINK, anticorps B55, anticorps MAP4K6, anticorps YSK2, anticorps ZC3, anticorps hMINK, anticorps hMINKbeta, anticorps MEKKK 6, anticorps Map4k6, anticorps RP23-122P1.6, anticorps Ysk2, anticorps misshapen like kinase 1, anticorps misshapen-like kinase 1, anticorps misshapen-like kinase 1 (zebrafish), anticorps MINK1, anticorps Mink1

Sujet:

Description: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

Gene: MINK1

Poids moléculaire: 150kDa

ID gène: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane