MYL2 anticorps (N-Term)

N° du produit ABIN6263471

Détail du produit anti-MYL2 anticorps

Antigène: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYL2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: MLC2 Antibody detects endogenous levels of total MLC2.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MLC2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, 1:100-1:500, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MYL2

Antigène: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Autre désignation: MYL2 (MYL2 Produits)

Synonymes: anticorps CMH10, anticorps MLC2, anticorps 2410014J02Rik, anticorps MLC-2, anticorps Mlc2, anticorps MLC-2v, anticorps Mlc2v, anticorps Mylpc, anticorps Mlc-2, anticorps myl2, anticorps zgc:136848, anticorps XMLC2, anticorps cmh10, anticorps mlc2, anticorps G2, anticorps MLC-2A, anticorps MLC2V, anticorps myosin light chain 2, anticorps myosin light chain, phosphorylatable, fast skeletal muscle, anticorps myosin, light polypeptide 2, regulatory, cardiac, slow, anticorps myosin, light chain 2b, regulatory, cardiac, slow, anticorps myosin light chain 2 S homeolog, anticorps myosin, light chain 2, regulatory, cardiac, slow, anticorps MYL2, anticorps Mylpf, anticorps Myl2, anticorps myl2b, anticorps myl2.S

Sujet:

Description: Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion, as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).

Gene: MYL2

Poids moléculaire: 19 kDa

ID gène: 4633

UniProt: P10916

Pathways: Myometrial Relaxation and Contraction