NEDD4-2 anticorps (Internal Region)

N° du produit ABIN6263580

Détail du produit anti-NEDD4-2 anticorps

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEDD4-2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: NEDD4L Antibody detects endogenous levels of total NEDD4L.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NEDD4L, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NEDD4-2

Antigène: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Autre désignation: NEDD4L (NEDD4L Produits)

Synonymes: anticorps NEDD4-2, anticorps NEDD4.2, anticorps RSP5, anticorps hNEDD4-2, anticorps nedd4, anticorps nedd4-2, anticorps NEDD4, anticorps Nedd4-2, anticorps 1300012C07Rik, anticorps Nedd4b, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, anticorps NEDD4L, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog, anticorps neural precursor cell expressed, developmentally down-regulated gene 4-like, anticorps NEDD4L, anticorps LOC776799, anticorps nedd4l.S, anticorps Nedd4l

Sujet:

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).

Gene: NEDD4L

Poids moléculaire: 112 kDa

ID gène: 23327

UniProt: Q96PU5

Pathways: Negative Regulation of Transporter Activity