NEK6 anticorps (Internal Region)

N° du produit ABIN6263593

Détail du produit anti-NEK6 anticorps

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK6 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: NEK6 Antibody detects endogenous levels of total NEK6.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NEK6, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NEK6

Antigène: NEK6 (NIMA (Never in Mitosis Gene A)-Related Kinase 6 (NEK6))

Autre désignation: NEK6 (NEK6 Produits)

Synonymes: anticorps 1300007C09Rik, anticorps si:ch211-167p9.4, anticorps ATNEK5, anticorps MOE17.17, anticorps NIMA-RELATED KINASE5, anticorps NIMA-related kinase 5, anticorps SID6-1512, anticorps NIMA (never in mitosis gene a)-related expressed kinase 6, anticorps NIMA-related kinase 6, anticorps NIMA related kinase 6, anticorps Serine/Threonine kinase catalytic domain protein, anticorps NIMA-related kinase 6 S homeolog, anticorps Nek6, anticorps nek6, anticorps NEK6, anticorps NEK5, anticorps nek6.S

Sujet:

Description: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.

Gene: NEK6

Poids moléculaire: 36 kDa

ID gène: 10783

UniProt: Q9HC98