OPA1 anticorps (Internal Region)

N° du produit ABIN6263823

Détail du produit anti-OPA1 anticorps

Antigène: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: OPA1 Antibody detects endogenous levels of total OPA1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human OPA1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur OPA1

Antigène: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Autre désignation: OPA1 (OPA1 Produits)

Synonymes: anticorps 1200011N24Rik, anticorps AI225888, anticorps AI847218, anticorps lilr3, anticorps mKIAA0567, anticorps MGM1, anticorps NPG, anticorps NTG, anticorps largeG, anticorps fk62d06, anticorps wu:fb77a10, anticorps wu:fk62d06, anticorps zgc:92092, anticorps OPA1, mitochondrial dynamin like GTPase, anticorps optic atrophy 1 (autosomal dominant), anticorps Opa1, anticorps OPA1, anticorps opa1

Sujet:

Description: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).

Gene: OPA1

Poids moléculaire: 111 kDa

ID gène: 4976

UniProt: O60313

Pathways: Tube Formation