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PIAS2 anticorps (N-Term)

PIAS2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264197
  • Antigène Voir toutes PIAS2 Anticorps
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Épitope
    • 10
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 57
    • 24
    • 20
    • 10
    • 8
    • 8
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 50
    • 6
    • 2
    • 1
    Lapin
    Clonalité
    • 54
    • 5
    Polyclonal
    Conjugué
    • 43
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIAS2 est non-conjugé
    Application
    • 46
    • 21
    • 13
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PIAS2 Antibody detects endogenous levels of total PIAS2.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PIAS2, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PIAS2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Autre désignation
    PIAS2 (PIAS2 Produits)
    Synonymes
    anticorps MGC83751, anticorps piasx, anticorps wu:fi05f09, anticorps PIAS2, anticorps 6330408K17Rik, anticorps AI462206, anticorps ARIP3, anticorps AU018068, anticorps Dib, anticorps Miz1, anticorps PIASxalpha, anticorps PIASxb, anticorps PIASxbeta, anticorps SIZ2, anticorps DIP, anticorps MIZ, anticorps MIZ1, anticorps PIASX, anticorps PIASX-ALPHA, anticorps PIASX-BETA, anticorps ZMIZ4, anticorps protein inhibitor of activated STAT 2 L homeolog, anticorps protein inhibitor of activated STAT 2, anticorps protein inhibitor of activated STAT, 2, anticorps pias2.L, anticorps PIAS2, anticorps pias2, anticorps Pias2
    Sujet

    Description: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.

    Gene: PIAS2

    Poids moléculaire
    68kDa
    ID gène
    9063
    UniProt
    O75928
    Pathways
    Signalistation JAK/STAT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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