PLK4 anticorps

N° du produit ABIN6264303

Détail du produit anti-PLK4 anticorps

Antigène: PLK4 (Polo-Like Kinase 4 (PLK4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK4 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: PLK4 Antibody detects endogenous levels of total PLK4

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PLK4

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur PLK4

Antigène: PLK4 (Polo-Like Kinase 4 (PLK4))

Autre désignation: PLK4 (PLK4 Produits)

Synonymes: anticorps CG7186, anticorps DmSAK, anticorps Dmel\\CG7186, anticorps PLK4, anticorps Plk4, anticorps SAK/PLK, anticorps SAK/PLK4, anticorps Sak, anticorps plk4, anticorps sak, anticorps SAK, anticorps STK18, anticorps 1700028H20, anticorps AI385771, anticorps Stk18, anticorps PLK-4, anticorps stk18, anticorps wu:fi33g07, anticorps Sak kinase, anticorps polo like kinase 4, anticorps polo-like kinase 4, anticorps polo-like kinase 4 (Drosophila), anticorps serine/threonine-protein kinase PLK4, anticorps SAK, anticorps PLK4, anticorps Plk4, anticorps plk4, anticorps LOC5571876

Classe de substances: Phage Protein

Sujet:

Description: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).

Gene: PLK4

Poids moléculaire: 95 kDa

ID gène: 10733

UniProt: O00444

Pathways: M Phase