PTPRB anticorps (N-Term)

N° du produit ABIN6264522

Détail du produit anti-PTPRB anticorps

Antigène: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPRB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: PTPRB Antibody detects endogenous levels of total PTPRB.

Homologie: Pig,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PTPRB, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PTPRB

Antigène: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Autre désignation: PTPRB (PTPRB Produits)

Synonymes: anticorps PTPRB, anticorps HPTP-BETA, anticorps HPTPB, anticorps PTPB, anticorps R-PTP-BETA, anticorps VEPTP, anticorps 3230402H02Rik, anticorps C130094E24, anticorps Ptpz, anticorps Rptpb, anticorps VE-PTP, anticorps Veptp, anticorps protein tyrosine phosphatase, receptor type B, anticorps receptor-type tyrosine-protein phosphatase beta, anticorps protein tyrosine phosphatase, receptor type, B, anticorps PTPRB, anticorps LOC100380677, anticorps Ptprb

Sujet:

Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Gene: PTPRB

Poids moléculaire: 224kDa

ID gène: 5787

UniProt: P23467