Mahogunin RING Finger Protein 1 anticorps (Internal Region)

N° du produit ABIN6264784

Détail du produit anti-Mahogunin RING Finger Protein 1 anticorps

Antigène: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mahogunin RING Finger Protein 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: RNF156 Antibody detects endogenous levels of total RNF156.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RNF156, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Mahogunin RING Finger Protein 1

Antigène: Mahogunin RING Finger Protein 1 (MGRN1) (Mahogunin, Ring Finger 1 (MGRN1))

Autre désignation: MGRN1 (MGRN1 Produits)

Synonymes: anticorps RNF156, anticorps 2610042J20Rik, anticorps mKIAA0544, anticorps md, anticorps nc, anticorps RGD1311862, anticorps mgrn1, anticorps wu:fi38c03, anticorps zgc:55978, anticorps mahogunin ring finger 1, anticorps mahogunin, ring finger 1, anticorps mahogunin ring finger 1, E3 ubiquitin protein ligase S homeolog, anticorps mahogunin ring finger 1, E3 ubiquitin protein ligase, anticorps mahogunin, ring finger 1a, anticorps MGRN1, anticorps Mgrn1, anticorps mgrn1.S, anticorps mgrn1, anticorps mgrn1a

Sujet:

Description: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).

Gene: MGRN1

Poids moléculaire: 66-72 kDa,55 kDa

ID gène: 23295

UniProt: O60291

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling