ZIC1/2/3 anticorps
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- Antigène Tous les produits ZIC1/2/3 (Zic1/2/3/4/5)
- ZIC1/2/3 (Zic1/2/3/4/5) (Zic Family Member 1/2/3/4/5 (Zic1/2/3/4/5))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ZIC1/2/3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- ZIC1/2/3 antibody detects endogenous levels of total ZIC1/2/3
- Réactivité croisée
- Humain, Souris
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ZIC1/2/3
- Isotype
- IgG
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- Indications d'application
- WB: 1:500~1:3000 IHC: 1:50~1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- ZIC1/2/3 (Zic1/2/3/4/5) (Zic Family Member 1/2/3/4/5 (Zic1/2/3/4/5))
- Autre désignation
- ZIC1/2/3 (Zic1/2/3/4/5 Produits)
- Sujet
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Description: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
Gene: ZIC1
- Poids moléculaire
- 51kDa
- ID gène
- 7545
- UniProt
- Q15915, O95409, O60481
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