PRKAA1/PRKAA2 anticorps (Thr172, Thr183)

N° du produit ABIN6280795

Détail du produit anti-PRKAA1/PRKAA2 anticorps

Antigène: PRKAA1/PRKAA2 (AMPK1/AMPK2)

Épitope: AA 110-190, Thr172, Thr183

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAA1/PRKAA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: AMPKα1/2 is a protein encoded by the PRKAA1 gene which is approximately 64 kDa. AMPKα1/2 is localised to the cytoplasm and nucleus. It is involved in RET signalling, mTOR signalling, AMP-activated protein kinase signalling, the regulation of TP53 activity and longevity regulating pathway. It is a catalytic subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, it activates energy-producing pathways and inhibits energy-consuming processes such as protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPKα1/2 is expressed in nervous system, liver, blood, intestine and kidney. Mutations in the PRKAA1 gene may result in obesity. STJ91581 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AMPKα1/2 protein.

Specificité: AMPKα1/2 Polyclonal Antibody detects endogenous levels of AMPKα1/2 protein.

Attributs du produit: Rabbit polyclonal to AMPKα1/2.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human AMPKalpha1/2 around the non-phosphorylation site of T183/172.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur PRKAA1/PRKAA2

Antigène: PRKAA1/PRKAA2 (AMPK1/AMPK2)

Autre désignation: AMPKalpha1/2 (PRKAA1/PRKAA2 Produits)

Synonymes: anticorps AMPK, anticorps AMPK2, anticorps AMPKa2, anticorps PRKAA, anticorps Ampk, anticorps Ampka2, anticorps 2310008I11Rik, anticorps A830082D05, anticorps AMPKalpha2, anticorps protein kinase AMP-activated catalytic subunit alpha 2, anticorps protein kinase, AMP-activated, alpha 2 catalytic subunit, anticorps PRKAA2, anticorps Prkaa2

Poids moléculaire: 63 kDa

ID gène: 5562

UniProt: Q13131