BCL6 anticorps (Internal Region)

N° du produit ABIN6282755

Détail du produit anti-BCL6 anticorps

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Épitope: AA 271-320, Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Bcl-6 is a protein encoded by the BCL6 gene which is approximately 78,8 kDa. Bcl-6 is localised to the nucleus. It is involved in cytokine signalling in immune system, gene expression and FoxO signalling pathway. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. It is mainly required for germinal centre formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. It forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Bcl-6 is expressed in germinal centre T- and B-cells and in primary immature dendritic cells. Mutations in the BCL6 gene may result in b-cell lymphomas. STJ96676 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bcl-6 protein.

Specificité: Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

Attributs du produit: Rabbit polyclonal to Bcl-6.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Bcl-6.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000

Commentaires:

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur BCL6

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Autre désignation: Bcl-6 (BCL6 Produits)

Synonymes: anticorps bcl5, anticorps laz3, anticorps bcl6a, anticorps znf51, anticorps zbtb27, anticorps MGC132260, anticorps Bcl5, anticorps BCL5, anticorps BCL6A, anticorps LAZ3, anticorps ZBTB27, anticorps ZNF51, anticorps B-cell CLL/lymphoma 6 L homeolog, anticorps B-cell CLL/lymphoma 6, anticorps B cell leukemia/lymphoma 6, anticorps bcl6.L, anticorps bcl6, anticorps BCL6, anticorps Bcl6

Poids moléculaire: 78 kDa

ID gène: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus