INPP5D anticorps (C-Term)

N° du produit ABIN6285711

Détail du produit anti-INPP5D anticorps

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Épitope: AA 1110-1190, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: SHIP-1 is a protein encoded by the INPP5D gene which is approximately 133,3 kDa. SHIP-1 is localised to the cytoplasm and cell membrane. It is involved in inositol phosphate metabolism, RET signalling, B cell receptor signalling pathway and cell surface interactions at the vascular wall. This protein falls under the inositol polyphosphate-5-phosphatase family. It functions as a negative regulator of myeloid cell proliferation and survival. SHIP-1 is specifically expressed in immune and hematopoietic cells. Mutations in the INPP5D gene result in cancers of the immune system. STJ95655 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of SHIP-1 protein.

Specificité: SHIP-1 Polyclonal Antibody detects endogenous levels of SHIP-1 protein.

Attributs du produit: Rabbit polyclonal to SHIP-1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human SHIP-1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
ELISA 1:40000

Commentaires:

Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: SHIP-1 (INPP5D Produits)

Synonymes: anticorps INPP5D, anticorps 256.t00004, anticorps 13.t00027, anticorps ship, anticorps ship1, anticorps AI323613, anticorps SHIP, anticorps SHIP-1, anticorps SHIP1, anticorps s-SHIP, anticorps SIP-145, anticorps hp51CN, anticorps inositol polyphosphate-5-phosphatase D, anticorps phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, anticorps inositol polyphosphate 5-phosphatase, anticorps inositol polyphosphate-5-phosphatase D L homeolog, anticorps INPP5D, anticorps LOC100446045, anticorps inpp5d, anticorps EHI_159880, anticorps EHI_153490, anticorps inpp5d.L, anticorps LOC100380693, anticorps Inpp5d

Poids moléculaire: 133 kDa

ID gène: 3635

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg