tau anticorps (pSer396)

N° du produit ABIN6288003

Détail du produit anti-tau anticorps

Antigène: tau (tau Protein)

Épitope: AA 650-730, pSer396

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp tau est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Tau is a protein encoded by the MAPT gene which is approximately 78,9 kDa. Tau is localised to the cytoplasm and cell membrane. It is involved in the apoptotic cleavage of cellular proteins, MAPK signalling pathway, CDK-mediated phosphorylation and removal of Cdc6 and development slit-robo signalling. It promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein. Tau is expressed in neurons. Mutations in the MAPT gene may result in Frontotemporal dementia. STJ90423 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Tau protein which only binds about S396 when S396 is phosphorylated.

Specificité: Phospho-Tau (S396) Polyclonal Antibody detects endogenous levels of Tau protein only when phosphorylated at S396.

Attributs du produit: Rabbit polyclonal to Phospho-Tau (S396).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Tau around the phosphorylation site of S396.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
ELISA 1:20000

Commentaires:

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: Tau (tau Produits)

Synonymes: anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps tau, anticorps PHF-tau, anticorps microtubule associated protein tau, anticorps MAPT

Poids moléculaire: 80 kDa

ID gène: 4137

UniProt: P10636