Granulin anticorps
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- Antigène Voir toutes Granulin (GRN) Anticorps
- Granulin (GRN)
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Granulin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human GRN
- Isotype
- IgG
- Top Product
- Discover our top product GRN Anticorps primaire
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- Indications d'application
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WB 1:500 - 1:2000
IHC 1:50 - 1:200 - Commentaires
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In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines, Present in inflammatory cells and bone marrow, Highest levels in kidney
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20C. Avoid freeze / thaw cycles.
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- Antigène
- Granulin (GRN)
- Autre désignation
- GRN (GRN Produits)
- Synonymes
- anticorps GRN, anticorps grn, anticorps wu:fb11g12, anticorps wu:fj18f05, anticorps MGC53354, anticorps DKFZp459H066, anticorps CLN11, anticorps GEP, anticorps GP88, anticorps PCDGF, anticorps PEPI, anticorps PGRN, anticorps epithelin, anticorps acrogranin, anticorps granulin precursor, anticorps granulin a, anticorps Granulins, anticorps granulin L homeolog, anticorps granulin, anticorps GRN, anticorps grna, anticorps grn, anticorps grn.L, anticorps granulin, anticorps ORF1 granulin, anticorps Grn
- Classe de substances
- Viral Protein
- Sujet
- Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
- Poids moléculaire
- 63.544 kDa
- ID gène
- 2896
- UniProt
- P28799
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