NUDT1 anticorps

N° du produit ABIN6292587

Détail du produit anti-NUDT1 anticorps

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUDT1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Affinity purification

Immunogène: Recombinant protein of human NUDT1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:20 - 1:50

Commentaires:

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur NUDT1

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Autre désignation: NUDT1 (NUDT1 Produits)

Synonymes: anticorps mutT, anticorps nudT1, anticorps MTH1, anticorps Mth1, anticorps 7,8-dihydro-8-oxoguanine triphosphatase, anticorps nudix hydrolase 1, anticorps nudix (nucleoside diphosphate linked moiety X)-type motif 1, anticorps mth1, anticorps Tsp_07498, anticorps nudt1, anticorps 8odp, anticorps NUDT1, anticorps Nudt1

Sujet: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Poids moléculaire: 22.52 kDa

ID gène: 4521

UniProt: P36639