CIC anticorps

N° du produit ABIN6292681

Détail du produit anti-CIC anticorps

Antigène: CIC (Capicua Homolog (CIC))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CIC est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human CIC

Isotype: IgG

Information d'application

Indications d'application: WB 1:200 - 1:2000

Commentaires:

Expressed in fetal brain

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur CIC

Antigène: CIC (Capicua Homolog (CIC))

Autre désignation: CIC (CIC Produits)

Synonymes: anticorps wu:fb93c01, anticorps CIC, anticorps 1200010B10Rik, anticorps mKIAA0306, anticorps capicua transcriptional repressor b, anticorps capicua transcriptional repressor, anticorps cicb, anticorps CIC, anticorps Cic

Sujet: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 163.82 kDa

ID gène: 23152

UniProt: Q96RK0